Sven Rottenberg

Cutting Edge Congress
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Sven Rottenberg, DVM, PhD, Dipl. ECVP

Institute of Animal Pathology (Vetsuisse Faculty) and Cancer Therapy Resistance Cluster (DBMR), Bern Center for Precision Medicine, University of Bern, Switzerland

From 1999-2004 Sven Rottenberg received a dual education in veterinary pathology (Dipl. ECVP) and molecular biology (PhD) at the University of Bern (Switzerland). In 2004 he joined the group of Piet Borst at the Netherlands Cancer Institute (NKI) in Amsterdam where he became a tenured staff member (associate professor level) in 2012. At the NKI Sven Rottenberg established a new research focus: the study of anti-cancer drug resistance using genetically engineered mouse models (GEMMs) of human cancer. In 2014 he returned to the University of Bern as head of the Institute of Animal Pathology. The focus of the Rottenberg group is to understand the underlying mechanisms of resistance to anti-cancer therapies, including both radio- and chemotherapy. His group has identified various mechanisms of PARP inhibitor resistance (e.g. loss of PARG or a dysfunctional 53BP1-REV7-shieldin-CST pathway), and thereby generated novel insights into basic mechanisms of the DNA damage response. In addition, using genome-scale functional genetic screens, his group found LRRC8A/D proteins to be relevant factors in platinum drug resistance and ERCC6L2 as a useful marker to predict radiotherapy response. Moreover, the Rottenberg group has generated unique preclinical models to study residual disease and they have pioneered the use of 3D cancer organoids to study therapy escape.

The research of the Rottenberg group is supported by the Swiss National Science Foundation, the European Research Council, the Swiss Cancer league, and the Wilhelm Sander Foundation.

5 selected publications (as corresponding author)

Francica, Mutlu et al. (2020). Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining. Cell Reports 32:108068.

Gogola et al. (2018).  Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality. Cancer Cell 33:1078-1093.e12.

Duarte, Gogola et al. (2018). BRCA-deficient mouse mammary tumor organoids to study cancer drug resistance. Nat Methods 15:134-140.

Planells-Cases et al. (2015). Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. EMBO J 34:2993-3008.

Xu et al. (2015). REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature 521:541-4.